|
KMID : 0387720160270020169
|
|
Korean Journal of Blood Transfusion
2016 Volume.27 No. 2 p.169 ~ p.173
|
|
|
A Case of Primary Anti-D Alloimmunization by RHD (c.1227G>A) DEL Red Blood Cell Transfusion
|
|
Yoon Jung
Ko Young-Eun
Kim Ha-Nui
Kim Jee-Yong
Jung Bo-Kyeung
Lee Sun-Ah
Oh Deok-Ja
Lim Chae-Seung
|
|
|
Abstract
|
|
|
|
The Rh blood group D antigen is the most immunogenic of all antigens, next to ABO antigens. Anti-D immunization is clinically important since it may cause clinical problems, such as severe hemolytic transfusion reactions and hemolytic disease of the newborn. DEL is an extremely weak D variant that cannot be detected by basic serologic typing and is typed as D-negative without the absorption-elution techniques and RHD genotyping. Of the DEL phenotype, RHD (c.1227G>A) allelic variant is the most common in Korea. The DEL phenotype has been considered to carry only a few D antigens to induce anti-D immunization, but a few cases have reported that this allelic variant is capable of inducing anti-D immunization in a D-negative recipient, for which it is clinical significant. Herein, we present a case of primary anti-D alloimmunization in a RhD negative patient after receiving RHD (c.1227G>A) DEL red cell transfusion identified by serological and molecular tests, including RHD genotyping.
|
|
|
KEYWORD
|
|
|
RHD genotyping, DEL, Anti-D antibody, Transfusion
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|